EFFECT OF CORDIA MILLENII EXTRACT ON REPRODUCTIVE HORMONE IN CISPLATIN INDUCED INFERTILITY IN FEMALE ALBINO RATS
Cordia millenii is a plant that belongs to the family Boraginaceae family, commonly known as African Cordia. In Nigeria, its Igbo name is okwe, omo in Yoruba and waawankurmii in Hausa. Various parts of Cordia millenii has been used as a restorative medicine for treatment of fever, general body weakness and stomach- ache. The present study was carried out to determine the effect of graded doses of ethanol leaf extract of Cordia millenii on fertility hormone in cisplatin induced infertility of female albino rats. Twenty four (24) healthy female rats weighing between 95 kg – 140 kg were divided into five groups. Group 1 served as the control, the animals in group 2 received an intraperitoneal dose of cisplatin (5mgkg-1 body weight). Animals in groups three and four received combination of oral dose of Cordia millenii ethanol extract 100 mgkg-1, 200 mg kg-1 body weight and cisplatin in 5 mg kg-1 , while animals in group five received an oral dose of Cordia millenii extract only (100 mgkg-1) for 14days. At the end of the study two rats were randomly selected from the cisplatin group for the mating study and blood samples were taken from the other rats in various groups for hormonal analysis. The result from the mating study revealed that cisplatin caused an irreversible infertility in the rats as no conception was achieved after 8 weeks. The estrogen level reduced in the cisplatin, low and high dose of Cordia millenii plus cisplatin and Cordia millenii extract only groups. Results from this study have shown the antifertility effect of Cordia millenii ethanol extract. Therefore, awareness should be created to avoid using Cordia millenii leaves in the treatment of infertility as currently; traditional health practitioners believe that this plant enhances fertility.
Keywords: Infertility, Cisplatin, hormone, ethanol extract, Albino rats.
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